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Treatment for Diabetic Kidney Disease - 0 views

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    Silver Line is one of the top hospital in Kochi, Kerala, India for Diabetic Kidney Care. Silver line provide expert surgeons for kidney transplantation, dialysis and treatment for kidney failure, diabetic kidney disease, diabetic kidney problems, chronic kidney disease and diagnosis the symptoms of kidney failure like fatigue, nausea and vomiting, heartburn, itchy skin.
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Stage 4 Kidney Disease with 28% Kidney Function Can I Live Like a Normal Person-Shijiaz... - 0 views

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    Stage 4 kidney disease with 28% kidney function can i live like a normal person ? In general, people with only 28% kidney function have to live with dialysis for the rest of their life, but fortunately, in our days they can have a chance to
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Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Base... - 0 views

  • The overloading of body iron plays a role as an oxidative stressor
  • active radicals can affect lipids, proteins, and deoxyribonucleic acid (DNA), resulting in tissue injury and dysfunction
  • Excess iron causes oxidative stress and induces inflammation, leading to renal disease progression
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  • Serum ferritin levels correlate with total body iron storage and systemic inflammation
  • The level of serum ferritin, an acute phase protein, is increased in an inflammatory environment
  • Previous studies have reported that elevated serum ferritin levels are associated with insulin resistance syndrome, hypertension, dyslipidemia, obesity, and metabolic syndrome as risk factors of CKD
  • elevated serum ferritin levels in hemodialysis patients predict higher mortality
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    great review and study: finds that elevated ferritin levels (> 200 ng/ml in men) was associated with increased chronic kidney disease in Korean study.
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Serum Testosterone Levels and Mortality in M... [Am J Kidney Dis. 2014] - PubMed - NCBI - 0 views

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    Not clear in its association here, but lower Testosterone was associated with increased mortality in men with chronic kidney disease not on dialysis.  This was found in the 2nd lowest quintile only.  What the authors did find was that diabetes and increasing BMI are were associated with increasing incidence of low T.  This studies definition of low Testosterone was <350 ng/dl.  This differs from other definitions.
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Imbalance in Sex Hormone Levels Exacerbates Diabetic Renal Disease - 0 views

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    Diabetes associated with low serum testosterone.  This study points to a 4.7 fold decrease.  This is accompanied by a 2.9 fold increase in estradiol.  Castration worsened this imbalance by decreasing the testosterone level further.  Likely the low T and increased aromatase activity aid in the development of diabetic renal disease. Numerous studies have shown that testosterone therapy improves glucose homeostasis.
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Creatinine 1.7 in Chronic Kidney Disease Is It Possible to Reverse It - 0 views

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    Creatinine 1.7 in Chronic kidney disease is it possible to reverse it ? As we all know there are many factors can induce creatinine level goes high, but no matter what causes, creatinine 1.7 can be reversed with timely treatment.
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Environmental Health | Full text | Arsenic in drinking water and cerebrovascular diseas... - 0 views

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    low levels of Arsenic in drinking water in Michigan shown to increase diabetes and other diseases
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Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the met... - 0 views

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    Fructose implicated in just about every chronic disease of aging through obesity.
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How to Avoid Dialysis for PKD Stage 3 Patients - 0 views

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    How to avoid dialysis for PKD stage 3 patients? As we all know, Polycystic Kidney Disease is a kind of genetic kidney disease, with the disease goes worse, doctors will recommend dialysis to patient.
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Environmental Health | Abstract | Arsenic in drinking water and cerebrovascular disease... - 0 views

  • suggest that exposure to low-to-moderate levels of arsenic in drinking water may be associated with several of the leading causes of mortality
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    low levels of Arsenic in drinking water contribute to cerebrovascular disease, diabetes, and cancer
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Magnesium metabolism in health and disease. [Dis Mon. 1988] - PubMed result - 0 views

  • Less than 1% of the total body magnesium is present in blood
  • A large segment of the U.S. population may have an inadequate intake of magnesium and may have a chronic latent magnesium deficiency that has been linked to atherosclerosis, myocardial infarction, hypertension, cancer, kidney stones, premenstrual syndrome, and psychiatric disorders.
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    Magnesium in health and disease
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Hay Alguna Esperanza para los Pacientes Etapa 5 Enfermedad Renal Crónica a Di... - 0 views

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    Is there any hope for stage 5 chronic kidney disease patient to live a high quality life?As we all know most of the patients with stage 5 will face dialysis or renal transplant, both of them can help them live better but meanwhile they also will bring some side-effect, so either of them can not ensure the kidney disease patient to enjoy a quality life.
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Hypercalcemia of malignancy and new treatment options - 0 views

  • Hypercalcemia of malignancy occurs as the result of direct bone metastasis and via humoral mechanisms such as parathyroid hormone-related protein (PTHrP) or 1,25-dihydroxyvitamin D mediated pathways
  • ectopic secretion of parathyroid hormone (PTH) has been implicated
  • Hypercalcemia due to osteolytic bone lesions is common in multiple myeloma, leukemia, and breast cancer
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  • Humoral hypercalcemia is predominant in squamous cell, renal cell and ovarian cancers, and lymphomas are associated with 1,25-dihydroxyvitamin D mediated hypercalcemia
  • 20% of cases of hypercalcemia of malignancy and is frequently encountered in multiple myeloma, metastatic breast cancer, and to a lesser extent in leukemia and lymphoma
  • Physiologic bone turnover requires the complementary activity of osteoblasts – mesenchymal stem cell-derived bone-forming cells – and bone-resorbing cells of monocyte and macrophage lineage known as osteoclasts
  • In local osteolytic hypercalcemia, the RANKL/RANK interaction results in excessive osteoclast activation leading to enhanced bone resorption and thus hypercalcemia
  • In addition, osteoclast activation is also mediated by malignancy secreted cytokines, including interleukin-1, initially termed “osteoclast stimulating factor”
  • Macrophage inflammation protein 1-alpha (MIP 1-alpha)
  • hypercalcemia is through extra-renal 1,25-dihydroxyvitamin D (calcitriol) production
  • 1% of cases
  • increased production of 1,25-dihydroxyvitamin D occurs nearly exclusively in Hodgkin and non-Hodgkin lymphoma with case reports of the same in ovarian dysgerminoma
  • 1-α-hydroxylase in the kidney, a process regulated by PTH
  • in 1,25-dihydroxyvitamin D induced hypercalcemia, malignant cells likely recruit and induce adjacent macrophages to express 1-α-hydroxylase, converting endogenous calcidiol into calcitriol.31 Calcitriol then binds to receptors in the intestine leading to heightened enteric calcium reabsorption with resultant hypercalcemia
  • this mechanism of disease is best conceptualized as an absorptive form of hypercalcemia
  • Ectopic production of PTH by malignant cells has been described in a handful of cases involving cancer of the ovary and lung, as well as neuroendocrine tumors and sarcoma
  • primary hyperparathyroidism and malignancy comprising nearly 90% of cases of hypercalcemia
  • an initial panel consisting of PTH, PTHrP, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D should be obtained
  • Lymphoma, a hypercalcemia due to 1,25-dihydroxyvitamin D mediated pathways, is implied by elevations in 1,25-dihydroxyvitamin D without concomitant elevations in 25-hydroxyvitamin D. In such cases, PTH is low and PTHrP undetectable
  • Treatment of hypercalcemia of malignancy is aimed at lowering the serum calcium concentration by targeting the underlying disease, specifically by inhibiting bone resorption, increasing urinary calcium excretion, and to a lesser extent by decreasing intestinal calcium absorption
  • mildly symptomatic disease
  • marked symptoms
  • hydration with isotonic fluid (if admitted), avoidance of thiazide diuretics, and a low-calcium diet
  • denosumab
  • Denosumab is an RANKL antibody that inhibits osteoclast maturation, activation, and function
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    hypercalcemia in cancer and treatments.
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Testosterone supplementation in aging men and women: possible impact on cardiovascular-... - 0 views

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    This study proposes that testosterone therapy aids in renal dysfunction in men.  However, they document that IL-6 and TNF-alpha and oxidative stress are a part of this process. What they fail to mention is that aromatase activity and conversion of T to E in men increases IL-6 and TNF-alpha.  Studies have also shown that T decreases TNF-alpha. Very likely, it is high aromatase activity causing the effects documented by this study.
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Kidney International - Abstract of article: Inflammation enhances cardiovascular risk a... - 0 views

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    Inflammation (point 5 of 5 points of wellness) increases CRP, which increases cardiovascular risk
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How to Deal with it When Blood Pressure Falls During Dialysis - 0 views

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    "Dear, doctor. Is there natural home remedies for kidney disease, especially for Creatinine 8.1 patients. Many patients asked about what to do when blood pressure falls during dialysis and consequences of doing dialysis. My father is a CKD stage 3 and sufferer from pain on his left side between and left hip and last rib. How to alleviate it?"
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